| 2024-01 |
Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis |
EMBO Molecular Medicine
|
| 2024-01 |
Disease association and therapeutic routes of aminoacyl-tRNA synthetases |
Trends in Molecular Medicine
|
| 2023-11 |
Prediction of Prognosis in Pancreatic Cancer According to Methionyl-tRNA Synthetase 1 Expression as Determined by Immunohistochemical Staining |
Cancers
|
| 2023-07 |
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1 |
EMBO MOLECULAR MEDICINE
|
| 2023-06 |
Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis |
Cell Host and Microbe
|
| 2023-05 |
EPRS1 Controls the TGF-β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell |
Molecular and Cellular Biology
|
| 2023-02 |
Ultra-thin membrane filter with a uniformly arrayed nanopore structure for nanoscale separation of extracellular vesicles without cake formation |
Nanoscale Advances
|
| 2023-01 |
Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses |
Cell Reports
|
| 2023-01 |
Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death |
Molecular Neurobiology
|
| 2023-01 |
Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug |
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
|
| 2022-12 |
O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine |
Nature Communications
|
| 2022-11 |
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1 |
Nature Communications
|
| 2022-10 |
Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors |
Bioorganic and Medicinal Chemistry Letters
|
| 2022-10 |
Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling |
Nature Communications
|
| 2022-07 |
Two distinct receptor-binding domains of human glycyl-tRNA synthetase 1 displayed on extracellular vesicles activate M1 polarization and phagocytic bridging of macrophages to cancer cells |
CANCER LETTERS
|
| 2022-05 |
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis |
NATURE COMMUNICATIONS
|
| 2022-05 |
Functional and pathologic association of aminoacyl-tRNA synthetases with cancer |
EXPERIMENTAL AND MOLECULAR MEDICINE
|
| 2021-12 |
Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Depleted Splice Variant of Aminoacyl-Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70((S)) |
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
|
| 2021-10 |
Clinical utility of methionyl-tRNA synthetase 1 immunostaining in cytologic brushings of indeterminate biliary strictures: a multicenter prospective study |
GASTROINTESTINAL ENDOSCOPY
|
| 2021-09 |
Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants |
STAR Protocols
|
| 2021-09 |
Diffusion-Based Separation of Extracellular Vesicles by Nanoporous Membrane Chip |
Biosensors
|
| 2021-07 |
Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction |
BIOORGANIC CHEMISTRY
|
| 2021-06 |
Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes |
NUCLEIC ACIDS RESEARCH
|
| 2021-06 |
Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis |
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
|
| 2021-04 |
Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation |
CELL REPORTS
|
| 2021-01 |
Aminoacyl-tRNA synthetases and amino acid signaling |
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
|
| 2020-11 |
Amyloid-like oligomerization of AIMP2 contributes to alpha-synuclein interaction and Lewy-like inclusion |
SCIENCE TRANSLATIONAL MEDICINE
|
| 2020-10 |
Extracellular vesicles derived from macrophages display glycyl-tRNA synthetase 1 and exhibit anti-cancer activity |
JOURNAL OF EXTRACELLULAR VESICLES
|
| 2020-08 |
Cell-based analysis of pairwise interactions between the components of the multi-tRNA synthetase complex |
FASEB JOURNAL
|
| 2020-06 |
Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2 |
MOLECULES
|
| 2020-06 |
An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody |
Biomolecules
|
| 2020-05 |
Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy |
JOURNAL OF MEDICINAL CHEMISTRY
|